Combined vaginal and oral low-dose oestrogen plus progestogen therapy improves dyspareunia, sexual experience, and quality of life in postmenopausal women, a small randomised, placebo-controlled trial finds.
Postmenopausal women aged 45 to 65 years received daily oral conjugated oestrogens (0.45 mg medroxyprogesterone (1.5 mg) tablet for six 28 day cycles along with 1 g conjugated oestrogen vaginal cream (0.625 mg) intravaginally or placebo.
The treated women had a significant decrease in frequency of dyspareunia. In addition, treatment was associated with improvement in level of sexual interest, and the frequency and pleasure of orgasm.
A randomised study of low-dose conjugated oestrogens on sexual function and quality of life in postmenopausal women.
Gast, MJ et al Menopause 2009; 16(2):247-256
Content Updated April 24 2009