12 August, 2013
Meningiomas, which arise from tissues that cover the brain and spinal cord, represent about a fifth of all brain tumors, and they affect women more often than men . The reason for a female predominance is not known, although most meningiomas express receptors for progesterone and some also express estrogen or androgen receptors . Most arise from the arachnoid villi in association with the dura mater or intracranial venous sinuses. Meningiomas are typically slow growing and may compress the brain, but they usually do not invade neural tissues or metastasize to distant sites. Many meningiomas are asymptomatic, discovered only as incidental findings at autopsy or on brain imaging studies performed for some other reason (e.g. ordered because of headache or light-headedness) .
In a nationwide case-control study, Danish investigators recently reported associations between menopausal hormone therapy (HT) and meningioma . Their findings, which are largely consistent with other observational research, are also notable from the perspectives of interpretation, perception, and validity.