AMS HP eNews Bulletin 26 October 2015


  Australasian Menopause Society  
Health Professionals eNews26 October 2015
  Welcome to AMS HP eNews for doctors and other healthcare professionals who have a special interest in women's health. The content covers information and resources relevant to menopause, midlife and the promotion of healthy ageing.


World Menopause Day 2015

World Menopause Day 2015



For World Menopause Day this year the International Menopause Society (IMS) highlighted that after menopause, the risk of memory loss increases, but simple lifestyle changes can help prevent the effects of ageing and maintain brain health and alertness.


In the White Paper: Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis the IMS undertook a systematic review and meta-analysis to identify the individually modifiable risk factors to ameliorate cognitive ageing.


Lead author Professor Victor Henderson commented: "Each of us is responsible for our own health, and many aspects of healthy ageing are under our direct control. These include, for example, smoking cessation and regular exercise. Concerns with memory and cognitive abilities are increasingly common in midlife and older adulthood...




Patient Information


What comes to mind  menopause and the aging brainWhat comes to mind – menopause and the aging brain?

This comprehensive booklet offers positive advice on preventative strategies to prevent cognitive decline. It explains the difference between cognitive decline and dementia, how to prevent memory loss in midlife and highlights the top 10 tips for women to improve brain health and function.



White Paper


white paperIndividually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis


A number of health and lifestyle factors are thought to contribute to cognitive decline associated with age but cannot be easily modified by the individual patient. The authors identified 12 individually modifiable interventions that can be implemented during midlife or later with the potential to ameliorate cognitive aging.


Note: The IMS has granted permission to individuals only to reproduce the copies of the review for their own personal use.   



Sitting Time, Fidgeting, and All-Cause Mortality    

Sedentary behaviors (including sitting) may increase mortality risk independently of physical activity level. Little is known about how fidgeting behaviors might modify the association. This study concludes fidgeting may reduce the risk of all-cause mortality associated with excessive sitting time, but more research is needed.  



Use of compounded hormone therapy in the United States  

The authors of this study also conclude that the widespread use of C-HT suggests a double standard among prescribers who acquiesce to patient demand for C-HT but otherwise prescribe FDA-approved medical therapies for treatment of hypertension, osteoporosis, and other midlife health concerns. The magnitude of C-HT use also reveals a double standard in regulation of the medication supply chain. Pharmaceutical companies are held to FDA-stipulated and enforced standards of manufacturing, requiring demonstrated efficacy, safety, and purity.   



'Natural' hormones hurting women - doctor  

New Zealand's Dr Anna Fenton, Past President of the Australasian Menopause Society and co-editor in chief of the journal of the International Menopause Society, specialises in women's health, and says she sees at least one patient every day suffering side effects from dodgy hormone treatments. Dr Fenton also said many doctors are seeing the same trend. 



Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline

The Endocrine Society has issued a Clinical Practice Guideline (CPG) on identifying women who are candidates for treatment of menopausal symptoms and selecting the best treatment options for each individual. The objective of this document is to generate a practice guideline for the management and treatment of symptoms of the menopause. The Treatment of Symptoms of the Menopause Task Force included six experts, a methodologist, and a medical writer, all appointed by The Endocrine Society. The Task Force developed this evidenced-based guideline using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence. The Task Force commissioned three systematic reviews of published data and considered several other existing meta-analyses and trials.



Menopause Essentials Update for Health Professionals 

me update


Menopause Updates are a new initiative of the Australasian Menopause Society in response to requests from many GPs for up to date evidence based information and guidance in managing women’s midlife health issues including menopause.


Topics include:

Menopause: What is it? ~ HRT: Risks and Benefits
How to Manage Menopause ~ Low Libido and Testosterone


Dr Jane ElliotDr Jane Elliot, MBBS, is Immediate Past President and a Life Member of the Australasian Menopause Society. 
Dr Deborah BatesonDr Deborah Bateson, MA, MSc, MBBS, is a Director of AMS, Medical Director and Director of Clinical Services, Family Planning NSW, and Adjunct Associate Professor, La Trobe University. 


CPD Points available

RACGP Activity 7701 – AMS Update on the Menopause – Menopause Essentials. 
Accredited for 6 category 2 points, QI&CPD 2014-2016 triennium

ACRRM Activity E1401AMSO AMS Update on the Menopause – Menopause Essentials.
3 Core points, 2014-2016 triennium

RANZCOG – AMS Update on the Menopause – Menopause Essentials
RANZCOG Approved O&G Meeting. Paper based CPD program participants can claim 3 CPD points (for full attendance) under the Meeting Attendance Category


Date and Venue

7 November 2015
Byron @ Byron Resort, Byron Bay, NSW



$50 for AMS Members, $75 for Non­‐members
This includes coffee on arrival, refreshments, lunch and a comprehensive delegate handbook.

Registration is now open at

For accommodation and tourist information, visit this website:




Join AMS for Member's only content

See exclusive commentary on studies such as:  


Dietary supplements lead to more than 20,000 ED visits a year  

A study conducted by the US Food and Drug Association and the Centers for Disease Control and Prevention found an estimated 23,000 emergency department (ED) visits in the United States every year are attributed to adverse events (AEs) related to dietary supplements such as herbal or complementary nutritional products and micronutrients (vitamins and minerals). These are commonly used in the United States, but national data on AEs are limited.


The researchers used nationally representative surveillance data from 63 US EDs obtained on 3,667 cases from 2004 through 2013 to describe ED visits because of AEs related to dietary supplements, which resulted in an estimated 2,154 hospitalizations (95% confidence interval [CI], 1,342 to 2,967) annually... 


Cerebral Venous Sinus Thrombosis in Users of a Hormonal Vaginal Ring

This article reports on four cases of cerebral venous sinus thrombosis in women using hormonal vaginal rings with negative thrombophilia testing who presented to our facility over a 2-year period. Three of the four women required mechanical thrombectomy in addition to anticoagulation, but all four women recovered and were discharged home with minimal or no neurologic deficits. Increased recognition of the thrombogenic potential of hormonal vaginal rings may promote earlier venous imaging and result in better clinical outcomes. 


Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair   

In this study, researchers from 177 institutions worldwide analyzed the DNA of about 70,000 women of European ancestry. They found more than 50 genetic variations, including 18 previously discovered ones, that seem to be linked to the age a woman reaches menopause. 


To Treat or Not to Treat: The Use of Hormone Replacement Therapy in Patients With Ovarian Cancer  

The surgical treatment of epithelial ovarian cancer (EOC) results in the abrupt induction of menopause in pre- and perimenopausal women, who account for approximately 20% of all patients with ovarian cancer. The loss of ovarian estrogen results in disruptive vasomotor symptoms, which can negatively affect quality of life, increases the risk of bone loss and fractures, and increases the risk of coronary heart disease (CHD). These adverse effects of the loss of ovarian function can be readily treated with hormone replacement therapy (HRT). However, many physicians treating patients with ovarian cancer have been reluctant to use HRT. 


Nonhormonal Management of Menopause-Associated Vasomotor Symptoms: 2015

The Position Statement was developed by a NAMS Advisory Panel that included clinician-researchers with special expertise in nonhormonal medical therapy, herbal therapy, behavioral therapy, and lifestyle approaches for vasomotor symptoms (VMS). They evaluated all the available literature on these therapies to develop the recommendations.  


Midlife ADHD in women: any relevance to menopause?
Some cognitive decline, particularly in the domains of executive functions, is common among menopausal women. A new study has examined the effect of the psychostimulant lisdexamfetamine (LDX) on subjective and objective cognitive function among menopausal women who report new-onset executive function complaints. 


Late peri/postmenopausal women have greater cardiovascular fat 
Growing evidence suggests a role of cardiovascular fat (epicardial + paracardial + aortic) in the pathogenesis of coronary heart disease. In order to study the relationship between deposits of cardiovascular fat and the menopause, El Khoudary and colleagues studied 456 women with an average age of 50 years from the SWAN heart cohort. Sex hormone levels were measured and cardiovascular fat volume was quantified by computerized tomographic scan. Late peri/postmenopausal women had greater volume of cardiovascular fat as compared with pre/early perimenopausal women independent of age and obesity. Lower estradiol concentrations were associated with greater cardiovascular fat volumes. The authors concluded that cardiovascular fat perhaps plays a role in the higher risk of coronary heart disease reported in women after the menopause.

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Tel: +61 3 9428 8738

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