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Hormone therapy timing and heart disease

Earlier initiation of hormone therapy is associated with less angiographic coronary artery disease in women with natural but not surgical menopause, a US study indicates.

More than 650 postmenopausal women undergoing coronary angiography for suspected ischaemia were followed for six years. 

Ever users of HT had significantly lower prevalence of obstructive CAD compared with never users, women with natural menopause initiating HT before age 55 had less severe CAD than never users but delaying therapy until 55 meant similar risks to never users. 

Researchers suggested the effect of HT use on reduced cardiovascular event rates was mediated by the presence or absence of angiographic obstructive atherosclerosis. 

Menopause. Apr 26 2011 online
Timing of hormone therapy, type of menopause, and coronary disease in women: data from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation

Content updated 25 May 2011

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